Endocrine Abstracts

Objectives: The Wnt-signalling pathway is involved in tumor development in various tissues. Wnt-signalling molecules are expressed in pancreatic beta-cells. In addition, Wnt-signalling regulates insulin secretion and the proliferation of pancreatic beta-cells in vitro and in animal models. However, it is not clear whether Wnts play a role for the development of human insulinomas. Therefore, we investigated the expression pattern of Wnt-signalling molecules in benign and...